Hajtaleb Medical Complex of Alternative and Complementary Medicine, Bojnurd, Iran Asian Journal of Traditional, Complementary and Alternative Medicines 2717-2783 2 Issue 1-2 2019 03 01 Improvement of Niemann Pick (B) Disease: Report of a Case Treated with Iranian Traditional Medicine 1 7 108131 10.22040/atcam.2019.108131 EN Niki Vakili Zahir Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran. Shabnam Khatami Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran. Mahnaz Sadeghian Department of Pediatric Gastroenterology, Ali-Asghar Children’s Hospital, School of Medicine, Iran University of Medical Sciences (I.U.M.S), Tehran, Iran. Shahrbanoo Nakhaie Department of Pediatric Gastroenterology, Ali-Asghar Children’s Hospital, School of Medicine, Iran University of Medical Sciences (I.U.M.S), Tehran, Iran. Seyyedeh Zahra Hosseini Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran. Mohsen Naseri Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran. 0000-0001-9239-768X Journal Article 2020 06 07 <strong>Background:</strong> Niemann-Pick Disease (NPD) is a rare autosomal recessive disorder associated with intracellular deposition of sphingomyelin and cholesterol storage within the lysosome. There are mainly three types of NPD namely types A, B, and C. NPD type B is generally later in onset with a good prognosis for survival into adulthood and usually with no neurological abnormalities.<br /><strong>Case Presentation:</strong> The patient, male, was born in 35 weeks of pregnancy. Failure to thrive started at around 4 months and the diagnosis of type B Niemann-Pick disease was made approximately at the age of 2 years. Currently, the patient is 10 years old and having undergone 3 years of Traditional Persian Diet, has had obvious improvement in growth and laboratory tests.<br /><strong>Conclusion:</strong> The NPD is no specific treatment, especially in modern medicine. Considering the significant improvement in the patient’s condition after an appropriate diet and traditional medicines, it seems that traditional medicinal therapies have great results in the treatment of NPD. In this study, we presented an innovation for NPD treatment by the use of a Traditional Persian diet. https://www.ajtcam.ir/article_108131_469bd5b7ec1ee8b3321271911560c76b.pdf